منابع مشابه
Death by a B Cell Superantigen
Amongst the many ploys used by microbial pathogens to interfere with host immune responses is the production of proteins with the properties of superantigens. These properties enable superantigens to interact with conserved variable region framework subdomains of the antigen receptors of lymphocytes rather than the complementarity determining region involved in the binding of conventional antig...
متن کاملComplement activation by a B cell superantigen.
Staphylococcal protein A (SpA), acting as a B cell superantigen, binds to the Fab region of human VH3+ Igs. Using SpA abrogated of its IgG Fc binding activity (Mod SpA) as a model B cell superantigen, we determined whether such an interaction causes complement activation. Addition of Mod SpA to human serum led to complement consumption and the generation of C3a. To determine whether this comple...
متن کاملHelper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge
Experimentally induced murine graft-vs.-host disease may be characterized by hypergammaglobulinemia, autoantibody formation, and immune complex-mediated organ system damage that mimics SLE. These autoimmune phenomena are mediated by abnormal Th-B cell cooperation, across MHC disparities, in which donor-derived allospecific Th cells recognize and interact with MHC class II antigens on the surfac...
متن کاملEffect of a putative B cell superantigen on complement.
Staphylococcal protein A (SPA), a cell wall component of S. aureus, binds not only to the Fc fragment of IgG, but also via an alternative site to the Fab fragments of immunoglobulins (Igs) independent of heavy chain isotype. ‘ J In man, this binding is restricted to Igs with vH3 heavy chains and occurs at a site(s) outside the conventional antigen-binding r e g i ~ n . ~ . ~ An increasing body ...
متن کاملPathogenesis of B-cell superantigen-induced immune complex-mediated inflammation.
Staphylococcal protein A (SpA) is representative of a new class of antigens, the B-cell superantigens (SAgs). These antigens bind to the Fab regions of immunoglobulin molecules outside their complementarity-determining regions. SpA, the best-studied B-cell SAg, reacts with the Fabs of most VH3+ immunoglobulins, which are expressed on 30 to 60% of human peripheral B cells. Therefore, B-cell SAgs...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2003
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20020552